AbstractBackground: Prostate cancer is a worldwide commonneoplastic disease in males. Loco-regional Staging of patho-logically proved Prostate cancer is of great impact on man-agement planning. Multi-parametric MRI is a novel highlysensitive modality in the evaluation of local behavior andaggressiveness of prostatic tumors.Aim of Study: This study aimed to assess the ability ofMult-Parmateric MRI in assessing the loco-regional featuresand aggressiveness of the proved prostatic cancer and howthat will impact the therapeutic individual planes.Methods: We evaluated 40 male patients (mean age 69years, range 56-87 years) with pathologically proved prostatecancer. They underwent a Multi-parametric MRI examinationat (1.5T Toshiba - USA) at Aswan University Hospital after at least 6 weeks after TRUS biopsy. MRI protocol included T2WI, diffusion-weighted MR and Dynamic Contrast (DCE). Each examination was analyzed to asses the diagnostic performance of multi-parametric MRI in the assessment of extra-capsular extension, seminal vesicles, and neurovascular bundle infiltration as well as regional lymphadenopathy with the histopathologic data from radical prostatectomy as the gold-standard reference.Results: Twenty patients (50%) out of 40 patients proved to have extra-capsular extension, 15 patients (37.5%) proved to have NVB infiltration, and 10 patients (20%) proved to have seminal vesicles invasion. Pelvic LNs were detected in 30 patients (75%). mpMRI in the loco-regional assessment of prostatic cancer showed high sensitivity and specificity.Conclusion: MRI is a non-invasive technique that provided a highly sensitive method in loco-regional evaluation and staging of the proved prostate cancer giving excellent impression regarding the aggressiveness of the tumor, leading to better and cost-effective management and save unnecessary invasive procedure.