Abstract Background: Tibial vessel disease (stenoses or occlusions) has a huge variety of outcomes either technical or clinical, which has an impact on the health authorities. Aim of Study: To locate clinical outcome predictors fol-lowing Plain Old Balloon Angioplasty (POBA) in diabetic patients with below knee atherosclerotic lesions causing Chronic Limb Threatening Ischemia (CLTI). Patients and Methods: Over one year, 67 patients (CLTI 100%) underwent infragenicular angioplasty. Our main interest was Major Adverse Clinical Outcome (MACO) of thelimb operated upon at follow-up which was adressed as clinical failure, need for subsequent endovascular or surgical revas-cularization or amputation. Results: Amputation free survival was seen in 88% with CLTI. Sound healing of wounds was achieved in 76% of cases with a mean value of healing timeof 10.7 months. Significant predictors of MACO were technical failure (p-value 0.002) and occlusive lesions (p-value 0.019). Freedom of MACO was achieved in 76.1%. Conclusions: Infragenicular angioplasty is a feasible therapeutic option in diabetic population. Type ofthe lesions in addition to smoking may be predictors of adverse outcome.