Abstract Background: The work is done at El-Hussien Hospital in last January. Aim of Study: To compare between the different effect of inspiratory muscle training and resistive diaphragmatic breath-ing on maximum inspiratory pressure and blood gases in patients with interstitial pulmonary fibrosis. Material and Methods: Measuring maximal inspiratory pressure and measuring blood gases. Thirty patients (13 males and 17 females) with interstitial pulmonary fibrosis were selected from El-Hussien Hospital from 2017-2018. Their ages range from 50 to 60 years old. Patients were participated in physical therapy program for eight weeks, patients are assigned into two groups (A-B) equally in number. Group (A): (7 males and 8 females) received inspiratory muscle trainer for deep inspiratory exercise for 8 weeks 3 sessions per week. Group (B): (6 males and 9 females) received resistive diaphragmatic exercise for 8 weeks 3 sessions per week. Results: Result showed that using inspiratory muscle training was more effective and fruitful than diaphragmatic breathing exercise on maximal inspiratory pressure and blood gases in interstitial pulmonary fibrosis as evidenced by sig-nificant increase in measuring maximum inspiratory pressure and blood gases. Conclusion: Inspiratory muscle trainer is more effective than diaphragmatic breathing in increasing maximal inspiratory pressure and blood gases in interstitial pulmonary fibrosis.