Abstract Backdround: Perfluorocarbon liquids (PFCLs) are widely used for years as an adjuvant in vitrectomy for repair of retinal detachment. Studies have been made to find out the post-operative effects of using PFCLs on the retina. A new imaging modality, Fundus Autofluorescence (FAF) can describe retinal displacement after vitrectomy clearly, which we could not describe it before with other imaging modalities. Aim of Study: To compare the incidence of retinal dis-placement after vitrectomy for repair of primary rhegmatog-enous retinal detachment (RRD) with and without the use of (PFCLs) using (FAF), and correlate them with final best corrected visual acuity (BCVA) and postoperative symptoms of distortion if present. Patients and Methods: A comparative, prospective, inter-ventional, randomized study. Thirty eyes of thirty patients having primary rhegmatogenous retinal detachment were divided into 2 groups. Group A: 15 eyes underwent pars plana vitrectomy without the use of PFCLs and group B: 15 eyes underwent pars plana vitrectomy with the use of PFCLs. Fundus Autofluorescence and amsler grid were done following absorption of intraocular gas. Results: Retinal displacement evident on FAF was (53.3%) of cases in group A (without PFCL), and (40.0%) of cases in group B (with PFCL), respectively (p-value = 0.464). PFCL use has no statistical significance in the incidence of retinal displacement. There was no statistically significant difference in the final mean BCVA between the two groups. Postoperative distortion was detected in (85.7%) of eyes showing retinal displacement on FAF. Conclusion: Retinal displacement is common following RRD repair and the use of PFCLs does not seem to affect the incidence of displacement.