Abstract Background: Glaucoma, the leading cause of irreversible blindness worldwide, can adversely impact quality of life for patients with visual field defects even if they are unaware of their diagnosis. In many populations, POAG is the most common form of the disease. Aim of Study: To measure peripapillary choroidal thickness in eyes with primary open angle glaucoma versus normal eyes using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging mode (EDI). Patients and Methods: The present study involved Ninety eight eyes of fifty adult patients were included in this obser-vational, case control study. These cases were collected from out-patient ophthalmic clinic of Ain Shams University Hospital during the period from March, 2018 till March, 2019. Results: A total 98 eyes of 50 patients were included in this observational study, with mean age of 52.26 years old. 48% of patients were males [24/50], while females were 52% [26/50]. These cases were divided into control group (50 eyes of 25 healthy controls) and glaucoma group (48 eyes of 25 patients). Conclusion: Peripapillary choroidal thickness (PCT) in primary open angle glaucoma cases shows no significant correlation nor in early or sever cases, so PCT has no role in early detection or follow-up of primary open angle glaucoma cases.