Abstract Background: Cavernous malformations are common vas-cular malformations composed of thin-walled sinusoids with no intervening brain parenchyma. Aim of Study: To evaluate the outcome of surgical resection of supratentorial cavernous malformations. Patients and Methods: 12 patients with supratentorial cavernous malformations operated upon in the period from June 2014 to December 2016 in Cairo University Hospitals were retrospectively studied for surgical outcomes including extent of excision, improvement of symptoms and development of complications. Pre-operative CT and MRI were performed in all patients in addition to angiography when the diagnosis was doubtful. Patients were followed-up clinically and radi-ologically for 1 year after surgery. Results: The study included 6 males and 6 females with an average age of 34.6 years. The lesion was frontal in 4, temporal in 4, parietal in 3 and occipital in 1 patient. Epilepsy was the most common presenting symptom occurring in 6 patients. Total resection was achieved in 11 (91.7%) patients. Total resection of the surrounding hemosiderin-stained brain was achieved in 9 (75%) patients. Improvement of pre-operative symptoms was achieved in 11 (91.7%) patients. Post-operative complications occurred in 2 (16.6%) patients. Conclusions: Surgical excision of symptomatic supraten-torial cavernous malformations provides good control of pre-operative symptoms and has a low rate of morbidity and mortality. The aim of surgery should always be total excision of the malformation.