Abstract Background: The antenatal care investigations is very important to determine the antenatal care problems, manage these problems and decrease the maternal morbidity and mortality. Aim of Study: Is to identify the medical pattern in the egyptian pregnant women from Kafr El-Sheikh according to the results of the booking test. Patients and Methods: Cross sectional study was done over 1260 pregnant women from 2015 to 2017 from the outpatient clinic of Obstetrics and Gynecology in Kafr El-Sheikh General Hospital, out of them 260 pregnant women stepped out of the study, all the pregnant women was asked to do the following antenatal care laboratory investigations, complete blood count, random blood sugar, Rh typing, cy-tomegalovirus (CMV) IgG antibodies, hepatitis B virus surface antigen, hepatitis C virus antibodies, high vaginal swap for bacterial vaginosis, urine analysis, all the data gathered for each woman in a file with her name for the statistical analysis. Results: Percentage of anemia was 47.1% with negative significant correlation with age, percentage of DM was 8.1%, percentage of Rh negative was 12.6%, percentage of CMV IgG was 85.7%, percentage of HBV was 2.4%, percentage of HCV was 7.9% with positive significant correlation with history of previous CS, percentage of bacterial vaginosis was 27% and percentage of UTI was 62%. Conclusion: A lot of women in Kafr El-Sheikh do not know the importance of the antenatal investigations and the control of the antenatal problems. Recommendations: There is need for give more concern about routine antenatal care investigations and it's importance and routine screening for anemia, DM, Rh, CMV, HBV, HCV, BV and UTI.