Abstract Background: Retinal Vein Occlusion (RVO) is the second most common cause of retinal vascular disease worldwide after diabetic retinopathy and its prevalence increases with age. Aim of Study: To evaluate the retinal microvasculature in human subjects central and branch retinal vein occlusion using optical coherence tomography angiography (OCT angiogra-phy). Patients and Methods: Twenty patients were recruited from the outpatient clinic in Al-Mashreq Eye Center. The study was performed during the time period between August 2018 and February 2019. OCTA (optical coherence tomography angiography) was performed at Mashreq Eye Center. All patients received a thorough explanation of the study design and provided their written consent. Results: Our study revealed that there was no statistically significant difference between CRVO and BRVO group re-garding demographic data, refraction, BCVA, FAZ, vessel density and thickness map. Also there was no statistically significant difference between CRVO group regarding FAZ, vessel density in 2 slices. There was no statistically significant difference between BRVO group regarding FAZ in 2 slices, vessel density in 2 slices. Conclusions: We concluded that with the ability to non-invasively visualize vascular flow, OCTA could serve as a new diagnostic tool for current ophthalmic research and clinical practice.