Abstract Background: Some clinical parameter and APACHE IV scoring systems allow assessment of severity of the disease in patients with interstitial lung diseases (ILD) and provide an estimate of in-hospital morbidity and mortality. Aim of Study: This study aimed to detect the ability of clinical parameters and APACHE IV score in predicting the mortality of interstitial lung disease patients in chest depart-ment. Patients and Methods: A prospective observational cohort study was performed at the Chest Department of Bab El-Sha'eria and Al-Hussein Al-Azhar University Hospitals. The study included patients with interstitial lung disease admitted between January 2015 and December 2019. Data were collected from 50 patients (29 female and 21 male) with age range from 24-61 years old (43.6±9.43). During the 1st day of admission, full history taking, HRCT Chest, Warrick score, pulmonary function test, arterial blood gases, APACH IV score, six minute walking test were recorded. Results: The study revealed that there; 38 (76%) patients with Interstitial Lung Disease survived and 12 (24%) non survived. There was a significant difference between PaO2, O2 sat, PaCO2, Systolic Pulmonary Artery pressure, and 6- minute walking distance, 4-meter walk time/seconds, APACH IV, Warrick score on admission between survived and non-survived subjects. Conclusion: Six-minute walk test, 4 meter walking time, systolic pulmonary artery pressure APACHE IV score and Warrick scoring high resolution C-T chest can be used as useful test in predicting mortality in interstitial lung disease.