Abstract Background: Oral cavity reconstruction is one of the most challenging and progressive areas in reconstructive surgery. In oral cavity reconstruction the main goals are prompt and safe restoration of mucosal integrity, avoid oro-cutanoeus fistula with restoration of the bony support whenever needed, followed by restoration of the function then lastly restoration of the form (aesthetics). Aim of Study: The aim of our study is to evaluate the feasibility of using pectoralis major muscle myocutaneous flap in reconstruction of oral cancer post excision defects. Patients and Methods: This is a retrospective study in which sixteen patients with oral cavity malignant tumors underwent surgical excision and immediate reconstruction, during the period from July 2016 to July 2019 with pectoralis major myocutaneus flap as regard peri operative evaluation and post operative complications. Results: This retrospective study included 16 patients with oral malignancy with reconstruction of the oral defect using pectoralis major myocutaneous flap. The mean duration of follow-up in all patients was 13.8 months (ranged from 6 to 30 months). From 16 patients, 4 patients (25%) patients had De-novo cancers, while the rest were recurrent cases. Conclusion: Pectoralis major myocutaneous flap is considered as an easy, simple method in cases of large oral cavity defects. It can be used as a back up or an alternative to free tissue transfer or even as salvage procedure.