Abstract Background: Recurrence of disease is one of the major problems in patients with breast cancer during the first 2 years after diagnosis. Now, considering advanced laboratory tech-niques and complementary therapies, the rate of breast cancer recurrence has decreased. Aim of Study: The rationale of this study is to discuss the clinico-pathological prognostic factors in HER2/neu positive breast cancer. Patients and Methods: This current study was conducted on 50 patients diagnosed with breast cancer. Patients in this study were underwent either Modified radical mastectomy (MRM) or Breast conserving therapy (BCT) with axillary lymph nodes dissection. The follow-up period varied between 12 months to 24 months. Results: No mortality related to surgery was reported. Outcome of surgery was flap necrosis in 2 patients (4%), seroma in 3 patients (6%) but infection only in one patient (2%). Recurrence was observed in ten patients (20%). Three patients (6%) died during their follow-up due to distant metastasis. All recurrent patients having grade N3 >9 positive lymph nodes; p-value; 0.0001. Conclusion: Prognostic factors in HER-2 positive patients with breast cancer play important roles and it is considered an indicator of recurrence and the predictor of overall survival. The most significant prognostic is axillary lymph nodes involvement.