Abstract Background: Retinoblastoma is the most common intraoc-ular tumor in children. There are two forms heritable and non-heritable. Leukocoria is the most common presenting sign, accounting for about 56.1% of cases. Strabismus is the second most common mode of presentation. Early retinoblastoma patients (group A and B ICRB) treated by systemic chemo-therapy in conjunction with local control have the higher rate of eye salvage. Aim of Study: To classify retinoblastoma patients presented to Oncology Unit of Ain Shams Department of Ophthalmology to international groups and study presentation, modalities of treatment and treatment outcome of group A and B patients. To see to what extent in Ain Shams Department of Ophthal-mology we succeed achieving eye salvage in early retinoblas-toma patients group A and B. Patients and Methods: This study involved patients have been treated at Oncology Unit of Ain Shams Department of Ophthalmology. Data was extracted from recorded files of patients in the period from January 2004 till January 2012. All patients data were subjected to refinement of: Age, sex, date of first visit, complaint, family history, fundus examina-tion, diagnosis, classification to international groups, treatment, follow-up. Results: Complete tumor regression had occurred in 90% of all group A and B patients following treatment with systemic chemotherapy plus focal laser thermotherapy. Enucleation was needed in 6.7% of all patients. Group A only patients had a 90% percentage of complete tumor regression, with only one patient died from pneumonia (one out of 30). Group B only patients had a 90.5% percentage of complete tumor regression, with only two patients had needed enucleation (2 out of 30). EBR was needed in 6.7% of all patients. Age at presentation mean was 1.09 year with range (0.1-3). Regarding presenting symptoms, 80% of patients presented with leuko-coria and 13.3% with squint. Family history was negative in 86.7% and positive in 13.3%. Conclusion: Our conclusion is that early retinoblastoma patients (group A and B ICRB) treated by systemic chemo-therapy in conjunction with local control have resulted in ocular salvage rates exceeding 90% for early intraocular disease.