Abstract Background: Pancreatic cancer is the fourth leading cause of cancer related deaths worldwide. It has poor prognosis especially in locally advanced tumours. Treatment of pancreatic tumours remains a challenge regarding their growth into the adjacent anatomical and vascular structures. Multidetector computed tomography (MDCT) plays an important role in diagnosing of patients with resectable and borderline resectable tumours. Evaluation of borderline resectable tumours should involve the accurate identification of the relationship between the tumour and the surrounding vessels and other vital struc-tures. Aim of Study: Evaluation of the role of CT angiography in the assessment of tumor vascular relationship in patients with pancreatic tumors in order to choose the proper treatment decision. Material and Methods: This study is a prospective study which was conducted in the Radiology Department of Man-soura University Hospital over the period from August 2016 to September 2019. This study included 79 patients, their ages ranged from 45 to 74 years old with mean age 58.3 years old. All patients were referred from oncology Center of Mansoura University and outpatient surgery clinics. The study was approved by our institution's ethics committee, and all patients gave their informed consent before inclusion in the study. CT scans were obtained with a MDCT scanner (Aquilion 64, Toshiba Medical Systems). CT protocols for pancreatic imaging vary at different institutions but typically include a multiphasic technique with a very thin section imaging and multiplanar reconstruction. Contrast enhanced images include: A late arterial or pancreatic phase and a portal or venous phase after injection of 100-120mL of intravenous non-ionic water soluble contrast material usually at rate of 4-5mL/sec. Results: This study included 79 patients, their ages ranged from 45 to 74 years old with mean age was 58.3 years. The most common affected site in the pancreas was the pancreatic head (47 lesions). All the lesions in our study were histopatho-logical proven malignant. The most common histopathological type in our study was pancreatic adenocarcinoma representing 61 lesions (77.21%). As regards the CT appearance of the pancreatic masses, most of the lesions were hypodense (71lesions). Detailed evaluation by CT angiography showed that the hepatic artery was involved in 35 cases, the SMA in 49 cases, the celiac trunk in 29 cases and the gartroduodenal artery in 47 cases. There was no arterial vascular involvement in 25 cases. Finally as regards the anatomical variations; accessory right hepatic artery was detected in 11 cases, Accessory left hepatic artery in 12 cases, replaced left hepatic artery in 14 cases, replaced right hepatic artery in 10 cases, replaced common hepatic artery in 9 cases and 23 cases showed no anatomical variants. Conclusion: Multidetector CT with CT angiography plays a major role in the diagnosis and staging of pancreatic carci-noma. The use of standardized technique and radiologic reporting method can improve the evaluation of the tumor-vessel relationship and precisely evaluate the arterial anatom-ical variants.