Abstract Background: Wet AMD is considered one of major causes of visual loss above age of fifty, which can be treated by anti-VEGF. Moreover the introduction of Microperimetry for functional evaluation of the macula allows more information about visual prognosis and effect of treatment on macular functions in eyes with AMD. Aim of Study: To evaluate location/stability of fixation and preferred retinal loci (PRL) before and after bevacizumab injection in wet Age Related Macular degeneration (AMD) using Microperimetry. Patients and Methods: 30 eyes with wet AMD underwent OCT and microperimetry before receiving bevacizumab and one month after last intravitreal injection of loading dose of bevacizumab (3 consecutive injections one month apart) to assess Location and stability of fixation. Results: There was improvement in stability of fixation by 30% after treatment with intravitreal bevacizumab in eyes with wet AMD. Conclusion and Message of the Study: Microperimetry is an important tool in evaluating location/stability of fixation and PRL in wet AMD.