Abstract Clinical practice guidelines of hepatitis E treatment post solid organ transplantation would undoubtedly help improve management of these cases. Whilst hepatitis E viral infection runs a benign course in healthy individuals, it can lead to persistent hepatitis and liver cirrhosis in immunocompromised patients including patients with solid organ transplantation. Available treatment options of these cases lack supporting robust evidence and they are derived from limited number of case series. There are no randomised clinical trials that help inform clinicians' decision making. This results in some gaps in the current guidelines that may require further attention. We hereby present a kidney transplant recipient who developed hepatitis E viral infectio