Abstract Background: As liver stiffness measured by FibroScan® can reflect the degree of liver fibrosis, liver stiffness meas-urement can predict the liver functional reserve. Aim of Study: To evaluate the relationship between liver fibrosis stage and the risk of post-operative hepatic decom-pensation in patients with liver cirrhosis undergoing hepate-ctomy for hepatocellular carcinoma. Patients and Methods: This prospective study was con-ducted on forty adult patients with HCV-related HCC eligible for hepatic resection between May 2015 and February 2017. Liver stiffness measurement by Fibroscan® was prospectively done for all enrolled patients. Patients' demographics, comor-bidities, laboratory and radiological data were collected. Results: Hepatic decompensation occurred in 14 patients (35%) after liver resection. Analysis of ROC curve of liver stiffness measurement done before resection revealed a value equal to or higher than 15.4KPa as the best cutoff value for liver fibrosis stage predicting post-operative hepatic decom-pensation with a sensitivity of 100%; specificity 100%, a positive predictive value 100% and negative predictive value of 100%. Conclusion: Liver stiffness measurement by transient elastography (Fibroscan®) may be a reliable tool to predict hepatic decompensation after liver resection for HCC.