Abstract Background: Percutaneous pedicle screw fixation is a minimally invasive spine surgery offers patients the benefits of decreased blood loss, fewer complications, and a more rapid return to daily activity. Aim of Study: To evaluate the percutaneous fixation as regard surgical procedure in the management of unstable dorsal and lumbar spine fracture and the clinical outcome. Patients and Methods: This study included 30 patients with traumatic thoracolumbar fractures. These patients were treated by percutaneous pedicle screw fixation. This study was conducted in Cairo University Hospitals from June 2011 to February 2014. They were neurologically free. Results: This series consist of 30 patients presenting with wedge and burst fractures of thoracic and lumbar spine (D12- L4). They were treated with percutaneous fixation. These patients were assessed pre-operative and post-operative looking into following points: (A) Clinical and functional assessment; (B) Radiological assessment (C) Intraoperative post-operative complication. Conclusion: Percutaneous spine fixation is a safe technique for treatment of thoracolumbar wedge and burst fractures with no neurological affection. It has the advantage of short time surgery, no blood loss, no muscle damage. Moreover, short hospital and bed stay are important benefits of percutaneous spine fixation.