Abstract Background: Laparoscopic sleeve gastrectomy is a rela-tively recent surgical technique that was estimated to account for about 5% of all bariatric surgery. Post-operative compli-cations detection could be done by either fluoroscopic gastro-grafin meal or multislice CT study before and after contrast administration. Aim of Study: To compare between the effectiveness of the main imaging modalities of early post-operative compli-cations of laparoscopic gastric sleeve surgery, including fluoroscopic gastrografin meal and multislice CT study. Patients and Methods: The study included 150 patients; 128 females (85%), and 21 males (15%). Their ages ranged from 26 to 55 years with mean age about 41 years. Patients were selected based on clinical suspicion of post-operative complications. Fluoroscopic gastrographin study and multi-detector CT study have been done. Operative findings corre-lation and clinical follow-up were the standard of reference. Results: Forty (30%) patients had matched fluoroscopic and CT findings, 110 (70%) patients had positive CT findings but, negative fluoroscopic findings. 0% had positive fluoro-scopic findings and negative CT findings. The leak was suspected in 80 patients, 5 patients with active bleeding that was clinically suspected, but the exact site of bleeding could not be identified by CT, 37 patients had serous fluid collection, splenic infarction was noticed in 5 patients, 3 patients developed post-operative hematoma one of them become infected, anterior abdominal wall hematoma seen in 5 patients, one patient developed portal vein thrombosis. Conclusion: Multidetector CT is better imaging modality in precise detection of early post laparoscopic sleeve gastrec-tomy complications than fluoroscopic gastrografin imaging.