Abstract Background: Various types of THA were used in treatment of different forms of osteoarthritis. In this study, we aimed to compare the early results of cementless versus hybrid Total Hip Arthroplasty (THA) in treatment of Posttraumatic Oste-oarthritis (PTOA). Aim of Study: Prospective comparative study. Patients and Methods: Twenty two cases were included in the study and they were divided into two equal groups; group A that performed cementless THA, group B that under-went hybrid THA. Perioperative circumstances of perioperative complications, operating room time, blood transfusion require-ments and length of hospital stay were reported. Post-operative evaluation was done using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Oxford Hip Score (OHS) and Harris Hip Score (HHS). Results: Demographic data did not differ between the three study groups (p>0.05). Group B showed a significantly longer operative time (p=0.001). However, complications rate, blood transfusion requirements and length of hospital stay did not differ between the study groups (p>0.05). Addi-tionally, no statistically significant difference (p>0.05) was detected between groups as regard as Patient Reported Out-come Measures (PROMs). Conclusion: Intrathecal dexmedetomidine is superior to both dexamethasone and bupivacaine alone regarding duration of analgesia and pain severity. Moreover, it has more rapid onset and longer duration of sensory blockade. No significant side effects were noted when compared to the remaining groups.