Abstract
Background: Chronic Kidney Disease (CKD) is a major health problem and its prevelence is increasing worldwide. Chronic kidney disease results in complex endocrinal and metabolic alterations. Anemia is a common complication of chronic kidney disease. There are various causes of anemia in chronic kidney disease patients on hemodialysis like mal-nutrition, infection, inflammation and hyperparathyroidism.
Aim of Work: The aim of the present work is to evaluate anemia among patients with ESRD on regular hemodialysis in Al-Gharbia governorate.
Patients and Methods: The study was done on 400 patients with ESRD on regular hemodialysis in more than one center for HD in Al-Gharbia governorate. All patients in this study were subjected to: History taking, full clinical examination, laboratory investigations done were intact Complete Blood Count (CBC), parathyroid hormone, serum phosphorus, ionized calcium, serum ferritin, transferrin saturation, serum albumin and C reactive protein after obtaining an informed consent.
Results: There was significant negative correlation between Hb and reticulocytic count (p=0.003 *), there was significant negative correlation between Hb and PTH (p=0.001*), there was significant negative correlation between Hb and S.albumin (p=0.019*), there was significant negative correlation between Hb and CRP (p=0.011*) there was positive significant corre-lation between Hb and T.Sat. (p=0.038*), Hb showed no significant correlation with serum ferritin, ionized calcium and phosphorus.
In Conclusion: Our finding suggests that many factors affect anemia in patients with ESRD on regular hemodialysis these factors include malnutrition, inflammation, iron defi-ciency and hyperparathyroidism.