Abstract
Background: Lichen planus is a chronic muco-cutaneous inflammatory disease that affects skin, mucous membranes, scalp, and nails. The exact pathogenesis of the disease remains unclear but cell-mediated cytotoxicity is regarded as a major mechanism of pathogenesis of lichen planus. Yes-Associated Protein (YAP-1) was originally identified in Drosophila as a key component of the Hippo pathway, which regulates cell proliferation, apoptosis and migration.
Aim of Study: The aim of this work was to study YAP-1 expression in cutaneous lichen planus.
Patients and Methods: This study was carried out on 20 patients with cutaneous LP and 10 normal skin specimens served as controls. All specimens were examined by H&E, and by immunohistochemistry for YAP-1 expression.
Results: There was statistically significant increase of YAP-1 expression in lesional skin of lichen planus patients in comparison to normal skin of healthy controls.
Conclusion: Increased expression of YAP-1 was found in cutaneous lichen planus in comparison to normal skin suggesting a possible role of YAP-1 in lichen planus patho-genesis.