Abstract
Background: Ischaemia-modified albumin (IMA), a novel biochemical marker for tissue ischaemia, was found to be associated with oxidative stress.
Aim of Study: Was to measure the level of ischemia modified albumin in sera of families with a case of rheumatic fever/rheumatic heart diseases whatever their presentation.
Patients and Methods: This study was done on 10 families of RF including 10 index cases, 10 mothers and 10 fathers and 20 siblings (total n=50) attending the RF clinic of pediatric department, All Patients had a full sheet, complete clinical examination and routine laboratory investigations (ESR, CRP, Blood group, CBC, ASOT and IMA) and ECHO. Control group, comprised 10 families including 10 mothers, 10 fathers and 30 siblings (total n=50).
Results: There was significant increase of IMA in between [cases of typical group as compared to control cases p(<0.001*)
-cases of atypical group as compared to control cases p(0.001*)
-cases of atypical group as compared to their siblings p(<0.001*), there was no significant increase of IMA in between (cases of typical group as compared to their siblings p(0.071) - siblings of atypical group as compared to control siblings p(0. 182)].
Conclusion: Our study concluded that serum IMA level and ASOT increased in children with ARF/RHD as well as their siblings which facilitate early detection and management of RF in siblings of a case of RF depending on positive family history and elevating anti-streptococcal antibodies and serum Ischemia modified albumin.