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52537

Correlation between Structural and Functional Changes in Glaucoma Patients Using Optical Coherence Tomography and Pattern Electroretinogram

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Last updated: 01 Jan 2025

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Abstract

Abstract
Background: To study the correlation between peripapillary retinal nerve fiber layer (RNFL) thickness measured with Optical Coherence Tomography (OCT) and pattern electroretin-ogram (pERG) parameters in primary open-angle glaucoma (POAG) patients.
Aim of Study: To study the correlation between peripap-illary RNFL thickness measured with OCT and pERG param-eters in POAG patients.
Patients and Methods: Fifty eyes of 50 patients diagnosed with POAG and 15 eyes of 15 normal subjects as control group, were enrolled in a prospective comparative study. The eyes in the POAG group were further subdivided into mild, moderate, and severe subgroups. All eyes had visual field testing using 24-2 Humphery standard automated perimetry, peripapillary RNFL average thickness using the 3.4mm circular scan of the Heidelberg OCT spectralis and pERG using CSO RetiMax device in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) guidelines.
Results: There were significant differences in the visual field mean deviation (VF MD), peripapillary RNFL average thickness & some pERG measured parameters (N95 latency & P50-N95 latency) between normal and POAG eyes as were as among the three subgroups of POAG. Significant correlation was found between peripapillary RNFL average thickness and N95 amplitude (p<0.001), P50-N95 amplitude (p=0.002), N95 latency (p=0.034) & P50-N95 latency (p=0.045). We found significant correlation between peripapillary RNFL average thickness and N95 amplitude (p=0.001), P50-N95 amplitude (p=0.017) in POAG patients.
Conclusion: Peripapillary RNFL average thickness is significantly correlated with pERG N95 amplitude & P50- N95 amplitude. In combination with OCT, pERG can be used to objectively assess functional loss in glaucoma.

DOI

10.21608/mjcu.2019.52537

Keywords

pERG, RNFL, OCT, POAG

Authors

First Name

ASMAA M. EL-GOHARY, M.Sc.;

Last Name

TAREK M. EID, M.D.

MiddleName

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Affiliation

The Department of Ophthalmology, Faculty of Medicine, Tanta University

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First Name

HISHAM A. HASBY, M.D.;

Last Name

HAZEM A. EL-BEDEWY, M.D.

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Affiliation

The Department of Ophthalmology, Faculty of Medicine, Tanta University

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Volume

87

Article Issue

March

Related Issue

7890

Issue Date

2019-03-01

Receive Date

2018-10-01

Publish Date

2019-03-01

Page Start

787

Page End

795

Print ISSN

0045-3803

Online ISSN

2536-9806

Link

https://mjcu.journals.ekb.eg/article_52537.html

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https://mjcu.journals.ekb.eg/service?article_code=52537

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95

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Original Article

Type Code

263

Publication Type

Journal

Publication Title

The Medical Journal of Cairo University

Publication Link

https://mjcu.journals.ekb.eg/

MainTitle

Correlation between Structural and Functional Changes in Glaucoma Patients Using Optical Coherence Tomography and Pattern Electroretinogram

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Article

Created At

22 Jan 2023