For patients with apical periodontitis, the development and maintenance of regenerative endodontic procedures can provide them with various biological and clinical benefits. These include the ability to improve the immune system's response to tooth decay, the establishment of a functional pulp-dentin complex, and the development of root formation. The mechanism by which this type of treatment is performed is regarded as a model for the restoration of a damaged tooth.
Numerous studies have been conducted on the various components of pulp tissue engineering, including the development of scaffolds, biomolecules, and stem cells. Unfortunately, these studies have revealed that the current clinical method for revascularization can lead to unfavorable outcomes.
The development and maintenance of regenerative endodontic procedures can provide them with various clinical and biological benefits. It can lead to the establishment of a stronger and more stable tooth, which can reduce the risk of fracture. Currently, the preferred method of treating patients with non-vital pulps is to undergo apexification. However, this procedure may no longer be the best option for those with severe apical periodontitis. Revascularization is a promising treatment method that has been shown to be safe and effective.
This review aims to provide a comprehensive overview of the various challenges that stem from the development and maintenance of regenerative endodontic procedures. It also highlights the current research findings that can help improve the clinical practice of this type of treatment.