Immediate post extraction implants are currently widely used , with this surgical technique a dental implant is placed after extraction of teeth in a fresh socket without waiting for any bone or soft tissue healing to reduce the treatment periods. Melatonin is physiologically existing in saliva and it was found to influence both bone regeneration and fibroblast activation as well as hyaluronic acid which distributed widely throughout neural,connective and epithelial tissues .
Aim: The aim of the present study was to evaluate the effect of topically delivered melatonin gel and hyaluronic acid on dental implants placed into fresh extraction sockets clinically and radiographically .Thirty two adult patients were randomly allocated into four equal groups Group (A): Each patient in this group received immediate implant placement (IIP) with no filling material around the implant .Group (B) : Each patient in this group received IIP simultaneously with topical hyaluronic acid as a filling material into bone gaps around implant .Group (C) : Each patient in this group received IIP with topical melatonin gel plus topical hyaluronic acid to fill the bone gaps around implant .Group (D) : Each patient in this group received IIP with melatonin gel to fill the bone gaps around implant .