Introduction: The aim of this study was to investigate the cyclic fatigue resistance of CM files (M3-ProGold, W3-Pro and M-Pro) and to compare it with that of the T-Wire (2Shape) and conventional NiTi (Revo-s) rotary files. Methods: Size 25/.06 of M3 Pro Gold, W3-Pro, M-Pro, 2Shape and Revo-s files (each n = 20) were evaluated inside two artificial canals [(60 curvature, 3 mm radius) and (45 curvature, 5 mm radius)] while submerged in distilled water at 37 ± 0.5. The NCF (number of cycles to failure) was calculated. The data of NCF were analyzed using ANOVA and Tukey post hoc tests (P ≤ 0 .05). Results: The CM files had a significantly higher NCF than the other files in severe and moderate canal curvatures. The 2Shape had a significantly higher NCF than Revo-s in both canal curvatures. Conclusion: CM files have greater resistance to cyclic fatigue than T-Wire and conventional NiTi rotary files.