Aim of the study: This study was performed to compare the pain experienced after application of chitosan as an intracanal medication, in comparison with calcium hydroxide, and Chlorhexidine gel.
Materials and Methods: thirty patients with lower first molar diagnosed as necrotic pulp with chronic apical periodontitis were included in the study. post-operative pain experienced after placement of the intracanal medication was evaluated after 6,12,24 and 72 hours using numerical rating scale (NRS).
Results: Patients with chitosan (CHI) showed significantly the lowest post-operative pain scores in comparison with CH and CHX gel at 6,12 and 24 hours after treatment P = 0.03, while at 72 hours no significant difference was detected between the three tested medicaments P= 0.16.
Conclusions: chitosan could be considered as a promising intracanal medicament, owing to its comparable reduction in post-operative pain compared to the other medicaments.
Keywords: Herbal medicine, Intracanal Medication, Root canal treatment, post-operative pain.