Abstract:
Background: To analyze tissue responses of Wistar rats to calcium hydroxide (calcipast), calcium hydroxide iodoform (calcipaste fort) and 2% chlorhexidine gel intracanal medicaments at different implantation time intervals.
Methods: 90 specimens were randomly implanted subcutaneously of rats dorsal surface with a polyethylene tubes containing the following substances:, calcium hydroxide (calcipast), 2% chlorhexidine gel and calcium hydroxide iodoform (calcipaste fort) intracanal medicaments (test groups). However subcuateneous implantations of 30 specimens of empty polyethylene tubes (control group) were performed; Rats were distributed according to time intervals of evaluation at 1, 2 and 4 weeks. The histological sections were stained with Harris hematoxylin and eosin then evaluations were made in a digital Microscope at X40, X100, and X400 magnifications for quantitative evaluations of inflammatory cells.
Results: It was observed that between the tested materials, calcipast fort |(group 4) showed the least inflammatory rats tissue reaction , followed by chlorohexidine (group 3) then calcipast group (group 2) at all tested time intervals in comparison to control group (group1).
Conclusion: Calcipast fort showed good biocompatibility when compared with chlorohexidine and calcipast intracanal medications.