Objectives: The aim of this study was to evaluate the reliability of software soft tissue prediction.

Materials and Methods: Computer-guided genioplasty was done for seven patients with a retruded chin followed by six months postoperative period of follow-up to evaluate the results. Materialize Mimics software was used for the simulation and 3-Matic software was used for guide designing and computing the comparison between the actual and simulated soft tissue. Paired Student “t" test was used to evaluate the accuracy of surgical guide, accuracy of prediction and to compare between the pre and post soft tissue segment changes.

Results: This study found that the software accuracy was an average of 92.86%, which is an all-simulation accuracy percentage that ranged from -2 to 2 mm and the mean of absolute error was 0.169.

Conclusion: This software was reliable in the prediction of soft tissue changes except in the submental region and the tip of the chin.