Background: Vitamin D (Vit. D) is responsible in the process of calcium homeostasis , among many other biological effects. Thus it plays an essential role in bone related diseases. Furthermore, several studies investigated the link between Vit. D plasma level and various conditions of periodontal diseases.
Objective: Therefore, the present study aimed to assess Vit. D3 [25(OH) D] gingival crevicular fluid (GCF) levels in individuals with different periodontal conditions. Subjects and methods: 60 GCF samples were taken from 60 individuals divided into 3 equal groups, healthy, gingivitis and periodontitis. Vit. D GCF level was assessed using ELISA technique. Results: There was a statistically significant difference between (gingivitis, periodontitis and healthy control) groups, with mean and SD [4.4 + 0.3 ng/ml, 3.5 + 0.4 ng/ml, 5.6 + 0.5 ng/ml] respectively (P value 0.001). Conclusion: The results are supporting the link between 25(OH) D GCF level and the periodontal condition. The study might be emphasizing the correlation between the periodontal disease and deficiency in Vit. D.