Abstract
Objective: This study was conducted to evaluate the biocompatibility of two bioactive materials, Cention N (CN) and ACTIVA bioactive, then compare the result with that of Mineral Trioxide Aggregate (MTA) as a retrograde filling materials. Methods: Sixty Albino male rats were used in the study, four polyethylene tubes were subcutaneously implanted into the rats, an empty one was used as a control group, and the other three tubes were filled with ACTIVA, Cention N and MTA-HP. Rats were then divided into three groups (n = 20 rats) following the sacrification time into three intervals: one, two and three weeks, then, the tissue specimens were analyzed histopathologically. The collected data were subjected to statistical analysis. Results: ANOVA test showed that the lowest inflammatory reaction was recorded for ACTIVA while a high degree of chronic inflammation was recorded for MTA group, with highly significant differences, P< 0.001. ACTIVA bioactive material exhibited observable decline of inflammation and fibrosis in a comparison to the control. Conclusions: The two bioactive materials showed a higher biocompatibility comparable to MTA. ACTIVA showed the highest degree of biocompatibility related to the decreased intensity of inflammation, with well-formed fibrous connective tissue conversion and improved healing patterns.