The purpose of this study is to compare the use of a herbal haemostatic agent to Platelet Rich Plasma (PRP) in the maxillary sinus after the Caldwell-Luc surgery for the closure of the Oro-Antral Fistula (OAF).

This study included 20 adult patients, who had an OAF that was treated using the Caldwell-Luc method. They were divided randomly into two groups: Group A: Surgicel soaked with herbal haemostatic agent was packed in the sinus prior to close the OAF. Group B: Surgicel soaked in PRP was packed in the sinus before closing the OAF. Clinical evaluations were performed at different intervals to assess postoperative pain, oedema, bleeding, and infection. Microbiological assessment was accomplished by comparing a swab taken intraoperatively from the maxillary sinus to a swab taken one week later from the pharyngeal posterior wall (post nasal discharge). After three months, a radiographic evaluation utilising CBCT was performed to assess the fluid level in the affected maxillary sinus.

The herbal haemostatic drug and PRP showed similar results in terms of pain, oedema, bleeding, and infection. Also, both groups were effective in decreasing the fluid level buildup. Conversely, the microbiological tests showed that bacterial growth declined more with the herbal agent than with the PRP.

As a conclusion, there were little postoperative complications with the herbal haemostatic medication and PRP. Both were also successful in lowering the amount of fluid in the maxillary sinus. The herbal haemostatic medication, on the other hand, surpassed PRP in terms of antibacterial activity.