Purpose: The purpose of this study was to correlate the water sorption and flexural strength of acrylic resin reinforced with three different fillers. Materials and Methods: A Flexural strength test using a universal testing machine was done for 132 heat-cured acrylic resin specimens reinforced with titanium oxide nanoparticle, aluminum oxide nanoparticle, silanated, and non silanated glass fibers (n=12). Another 132 discs with the same fillers were evaluated for water sorption at 37°C ± 1°C using a four-digit electric balance. Specimens were stored in distilled water for 120 days. Statistical analysis was done using Pearson correlation (p < 0.05) to correlate the water sorption and the flexural strength at each nanoparticle concentration. Results: The correlation between the water sorption and the flexural strength was positive for the titanium oxide and aluminum oxide nanoparticles, and negative for the glass fibers specimens. However, these correlations were non-significant. Conclusion: Water sorption of heat-cured acrylic resin has no correlation with the flexural strength with the addition of titanium oxide nanoparticle, aluminum oxide nanoparticle, silanated and non silanated glass fibers