Aim of the study: This study evaluated the effect of obturation technique on the fracture resistance of endodontically treated teeth obturated with bioceramic sealers compared to resin-based sealers. Methods: Ninety-one (n=91) freshly human extracted single rooted teeth were selected. The samples were biomechanically prepared and classified according to the obturation technique and type of the sealer used into five groups as follows: Group 1 (n=21) obturated with cold lateral compaction technique using gutta-percha and AD-seal sealer (Meta Biomed, Korea). Group 2 (n=21) obturated with warm vertical compaction technique using gutta-percha and AD-seal sealer. Group 3 (n=21) obturated with cold lateral compaction technique using gutta-percha and MTA filapex sealer (Angelus, Brazil). Group 4 (n=21) obturated with warm vertical compaction technique using gutta-percha and MTA filapex sealer. Group 5 (n=7) Control group (unobturated). The samples were further classified according to the observation time into: subgroup A (n=7) evaluated after one week, subgroup B (n=7) evaluated after two weeks and subgroup C (n=7) evaluated after one month. Samples were loaded vertically after obturation using Universal Testing Machine until fracture. Results: MTA filapex group showed higher fracture resistance values than the other groups with no significant difference. No significant difference was found between the subgroups evaluated at different time intervals. Conclusion: The technique of root canal obturation didn't significantly affect tooth fracture resistance of either teeth obturated with Bio-ceramic sealer or resin sealer at different time intervals.