Aim:the aim of the current study was to evaluate the effect of injectable platelet rich fibrin (i-PRF) revascularization technique VS conventional endodontic treatment on the periapical healing of mature permanent teeth with periapical periodontitis. Materials and Methods: A total of 30 patients with apical periodontitis related to permanent central incisors were included in the study. The control group (n=15) has undergone conventional root canal treatment using crown down technique on 2 visits with calcium hydroxide intracanal dressing in between visits and obturation was done using cold lateral compaction technique. The intervention group (n=15) has undergone regenerative procedures. Regenerative protocol was carried out using 1.5% sodium hypochlorite irrigation and DAP intracanal medicament for 3 weeks. At the second visit, i-PRF was prepared and injected inside the root canal. The orifice was sealed with MTA followed by double sealing of the access by glass ionomer and composite-resin restoration. Clinical and radiographic evaluation was done for 1, 3, 6, 9, and 12 months, and CBCT imaging was done after 12- month follow-up period. Results: The i-PRF group recorded more decrease in the lesion size than the control group. However, the difference was not statistically significant yet, there was a highly significant statistical difference between the preoperative and postoperative measurements with great lesion size reduction within the i-PRF group Conclusion: i-PRF revascularization is an effective treatment of apical periodontitis in permanent teeth with mature apex.
Key words: Regeneration, i-PRF, Mature teeth, Apical healing, Root canal treatment, Pulp revascularization.