Aim: The current study was conducted to compare between reminerlization potential of tri-calcium phosphate plus fluoride versus casein-phosphopeptide/amorphous-calcium phosphate in caries white spot lesions.

Methodology: white spot lesions in anterior teeth of post orthodontic patients received randomly two types of remineralizing agents, clinpro tooth crème or MI paste plus, both materials were applied according to the manufacturer's instructions. White spot lesions were evaluated at base line one month ,3, 6 months follow up periods by two blinded assessors to assess patient satisfaction using VAS score and color change by Vita Easyhshade.

Results: One-way ANOVA followed by post-hoc Tukey's test showed that within each remineralizing agent, there was no statistically significant difference in L* mean values between different evaluation time periods.
Independent Student-t test showed that at each evaluation time, there was no statistically significant difference in L* mean values between both remineralizing agents. Two-way ANOVA showed that the two independent variables “remineralizing agent" (P<0.004) and “evaluation time" (P<0.0001) had significant effect on patien. T6 revealed the significantly highest VAS mean values; followed by T3; then T0 and T1 which were statistically similar but
at each evaluation time, there was no statistically significant difference in VAS mean values between both reminerailizing agents.

Conclusions:
1. Both clinpro tooth crème and mi paste plus has acceptable reminerlaization potential and beneficial effect in masking white spot lesions
2. There is gradual increase in patient satisfaction up to 6 months but it did not reach to the maximum patient satisfaction in masking white spot lesions.