PURPOSE: This study aimed to evaluate of knowledge, attitude, and practice regarding the recommended infection control measures among postgraduate students in several dental schools. SUBJECTS & METHODS: A cross sectional study was conducted among a group of postgraduate students in Cairo University using a self-administered questionnaire to evaluate their level of knowledge attitude, and practice regarding infection control measures. RESULTS: The response rate was 96%. Interesting areas were: Only 40% of the sample could describe the proper method of hands washing. Moving around while wearing face masks and protective gowns was reported by 32% and 28% of the sample, respectively. Data also showed that only 48% of the students had been vaccinated with required vaccines. Unfortunately, only 24% of sample displayed correct knowledge about the infections with the highest risk of transmission in the dental setting, whereas 90% knew how to handle an accidental needle prick. The overall data showed that the mean knowledge was 63.72%, attitude was 50.52% and practice was 60.42%. Knowledge scores ranged from 6-12/14; attitude scores were from 3-11/11 and finally practice scores from 2-9/10. CONCLUSIONS: This study revealed inadequate levels of knowledge, attitude, and practices toward infection control and that more training in both educational and practical fields is highly recommended.