Aim: to evaluate effect of chemo-mechanical caries removal on micro-tensile bond strength (µTBS) of composite using universal adhesive to caries affected dentine. Materials and methods: 64 permanent molars were used. 32 were sound and the other (32) were carious. Carious molars were divided into four groups as followed Group 1: caries was removed by Carisolv then universal adhesive was applied with etch and rinse approach followed nanohybrid composite to be tested with µTBS test after 24h. Group 2: as group (1) but tested after 3 months. Group 3: same as group (1) but using self-etch mode and tested after 24h. Group 4: as group (3) but tested after 3 months. Sound molars were divided into four groups according to bonding mode and according to the time of bond strength testing. Carisolv was applied according to manufacturer's instructions. The universal adhesive used with both approaches following manufacturer's recommendations. Nanohybrid composite was packed. For delayed groups specimens were stored in distilled water for 3 months. The specimens were cut to produce 1mm2 beam-shaped specimens for µTBS test. The fractured specimens were examined to determine mode of failure. Results: there was a statistically significant difference in µTBS values between different adhesive approaches at each storage time. Etch & Rinse approach yielded significantly highest µTBS mean values in both Caries affected dentin and sound dentin for both times. Conclusion: the etch and rinse approach is the indicated approach for bonding of the used universal adhesive to caries affected dentin especially after chemo-mechanical caries removal.