Purpose: The purpose of this study is to evaluate the change in color stability of maxillofacial silicon after exposing it to natural weathering and disinfection using neutral soap (shampoo). Material and Methods: 60 specimens were prepared from addition linking vinyl polydimethyl siloxane and divided into 3 groups (n=20). The specimens were then conditioned differently as follows, Group I: Dark room storage (control group); Group II: Neutral soap disinfection; Group III: Outdoor natural weathering for 2 months. The color changes of the specimens were measured using a Reflective spectrophotometer (X-Rite, model RM200QC, Neu-Isenburg, Germany) using the Commission Internationale de I'Eclairage (CIE).5 The measurements were taken after 1 month then after two months (follow up period). Results: There was insignificance increase in color change in neutral soap (shampoo) group. There was significance increase in color change in natural weathering group. Also there was significance difference between groups after 1 month and two months. Conclusions: Exposure to outdoor natural weathering and the disinfection with neutral soap (shampoo) causes color alteration of the maxillofacial silicone.