Purpose: aim of the study was to compare the bond strength of nanohybrid composite artificial teeth (NHC) and two types of denture base material ( acrylic denture base material and thermoplastic monomer free semi-rigid micro crystalline polymer denture base material (Karadent) . Material and Methods : nanohybrid composite teeth (premolars) was sliced equally , grooved for increasing contact surface and attached to 16 discs of denture base material (8 for each group), then the discs where grouped into two groups . The samples were subjected to tensile forces till failure by using the Instron Universal testing machine. Results : bonded nanohybrid composite teeth (NHC) to conventional acrylic denture base disc specimens showed better results in comparison to thermoplastic monomer free semi-rigid micro crystalline polymer denture base materials ones. Conclusion : it is recommended to use NHC teeth more often with conventional acrylic denture bases than thermoplastic monomer free semi-rigid micro crystalline polymer denture base materials.