Aim: The aim of this study was to evaluate bone regeneration of maxillary cystic defect grafted with puerarin with calcium sulphate granules versus calcium sulphate granules as a solograft.
Materials and Methods: This was a randomized controlled clinical trial conducted on 20 patients suffering from maxillary cystic lesions with size more than 3 cm2 indicated for enucleation without the need for resection or plate reconstruction.
In the first group (A): Bony cavities were grafted by Puerarin mixed with hemihydrated calcium sulphate bone graft granules, while in the second group (B): The bony cavities were grafted by hemihydrated calcium sulphate bone graft granules only. All patients were followed up for 6 months recording the progress of the healing both clinically and radiographically via CBCT.
Results: Surgeries went uneventful in patients of both groups. No notable complications occurred during the surgical procedures and the healing period of the two groups. Radiographic results after 6 months showed that there was a significant decrease in cyst volume in the purerein group compared to the other group.
Conclusions: Puerarin is a promising graft material with probably an osteoinductive role, an issue that needs more researches to optimize its use and to understand its bone forming mechanism.