This study aimed to evaluate the effect of bioceramic sealers on the fracture resistance of endodontically treated teeth compared to resin-based sealers and zinc oxide and eugenol based sealers. Methods: Seventy (n=70) freshly human extracted single rooted teeth were selected. The samples were biomechanically prepared and classified according to the type of the sealer used into four groups as follows; Group 1 (n=21) obturated with gutta-percha and Endofill sealer (Dentsply, Germany). Group 2 (n=21) obturated with gutta-percha and AD-seal sealer (Meta Biomed, Korea). Group 3 (n=21) obturated with gutta-percha and MTA filapex sealer (Angelus, Brazil). Group 4 (n=7) Control group (unobturated). All samples were kept in saline until evaluation. The samples were further classified according to the observation time into: subgroup A (n=7) evaluated after one week, subgroup B (n=7) evaluated after two weeks and subgroup C (n=7) evaluated after one month. Samples were loaded vertically after obturation using Universal Testing Machine until fracture. Results: MTA filapex group showed higher fracture resistance values than the other groups with no significant difference. No significant difference was found between the subgroups evaluated at different time intervals. Conclusion: Neither the type of root canal sealer nor the time lapsed affects fracture resistance significantly.