Purpose: To evaluate the effect of incorporation of 0.1%, 0.3%, and 0.5% concentrations of titanium oxide, aluminum oxide, and silica nanoparticles in the heat-cured acrylic resin denture base on the peel bond strength to a silicone denture liner. Methods: A total number of 100 heat-cured acrylic resin samples were prepared and classified into a control group and three groups according to the type of nanoparticle. Each group was classified into three subgroups according to the concentration of the nanoparticle (n=10). A Silicone based-soft liner was added over the acrylic resin specimens, and the peel bond strength was measured using the peeling bond strength test at an angle of 90°. Statistical analysis was done using a Two-way ANOVA test for interactions between peel bond strength and the different nanoparticle materials and their concentrations. Results: Two-way ANOVA showed that the three nanoparticles and different concentrations did not affect the peel bond strength. Conclusion: The nanoparticles in this study were not effective in increasing peel bond strength at the studied concentrations.