This study aimed to evaluate the anti-inflammatory effect of TQ-PLGA/PVA in treatment of oral carcinogenesis. Nanoparticles were fabricated via emulsification-solvent technique. Their characterization including the morphological analysis and size distribution on NPs performed using TEM and the structure composition was carried out via the FTIR. The charge determined via the DLS and ZP analysis. This study was carried out on 24 hamsters and divided into: group A served as negative control, group B was painted with DMBA for 6 weeks then subdivided into three subgroups: B1 served as positive control, B2 was injected with TQ, B3 was injected with TQ-PLGA. Assessment of the blood cells counts, histologically, immunohistochemically through detection of TNF-α protein were performed. Comparisons between groups were performed using ANOVA. The results showed proper encapsulation for TQ-PLGA, significant regression in tumors histologically, marked improvement in blood cells and expression levels of TNF-α protein. Conclusion: systemic application of TQ-PLGA was considered a promising chemo-therapeutic agent in tumors regression.