Purpose This study was conducted to radiographically evaluate the effect of two different superstructure CAD/CAM fabricated materials, on crestal bone loss around immediately loaded implant. Materials and Methods A total of twelve healthy patients having mandibular bilateral missing first molars with acceptable bone volume were selected based on specific inclusion and exclusion criteria, each patient received a CAD/CAM monolithic zirconia, in one site, while the other site received a CAD/CAM Enamic superstructure, in 48 hours after implant insertion. Implants and abutments were examined for stability, gingival and periodontal health prior to crown cementation. Radiographic evaluation was done immediately at the time of crown cementation then at 6 and 12 months. Results Marginal bone loss was measured at two points, the most buccal crestal bone, and the most lingual crestal bone. Radiographic results showed no significant difference regarding mean MBL between Zirconia and Enamic on 6 and 12 months. Conclusion Immediate loading of a single mandibular molar implant with the final restoration seem to be a reliable technique when certain parameters are respected. Type of implant superstructure material has no significant influence on the bone supporting the implant within the time period of this study.