objective: The purpose of this study was to present experience using cyanoacrylate tissue glue in fixation of onlay bone grafts used in different craniofacial reconstruction situations   design: Prospective analysis of patients with craniofacial defects including nasofrontal encephalocele and post traumatic craniofacial fractures repaired by onlay bone grafts. setting: Institutional center   patients/participants: A total of 27 patients presented with nasofrontal encephalocele (5) and post traumatic craniofacial fractures (22). interventions:  Reconstruction  of  nasofrontal  defects  using  onlay  bone  grafts  fixed  by cyanoacrylate tissue glue   outcome measures: Patients had repair using bone grafts fixed by cyanoacrylate tissue glue between 2010 and 2013. Patients' photographs, and clinical records, were collected. The technique of defect reconstruction and method of bone grafts securing it in its position is described in this study.   results:  Patients were followed up over a mean period of 12.6 months to clinically check the stability of the reconstruction, and the contour of the cranium. All patients showed uneventful healing without complications. Conclusions:  This  technique  offered  a  secure  method  of  onlay  bone  fixation  during reconstruction. Further researches are needed to show this technique advantages and drawbacks.