This study aimed to: evaluate the sealing ability of AH Plus sealer, IRoot SP sealer, and Epiphany-Resilon root canal filling system by Dye extraction method. Methods: 45 freshly extracted single rooted human teeth were instrumented with Revo-S; the sequence used was SC1, SC2, SU, AS30, AS35, and AS40 taper 0.06. The prepared specimens were then divided randomly into Negative controls (n = 9) and Positive controls (n = 9); the negative controls were completely covered with three layers of varnish, and the positive controls were enlarged, but not root filled. The remaining 27 teeth were then randomly divided into three groups of 9 teeth each according to the type of sealer used, as the following: Group 1 (AH Plus sealer), Group 2 (IRoot SP sealer), and Group 3 (Epiphany-Resilon root canal filling system). Apical leakage evaluation was done by dye extraction methods. Data were statistically analyzed. Results: The positive control showed total dye absorbance of 5000, while negative control samples had a low absorbance of 75. The mean absorbance values were 370, 315, and 400 for Group 1 (AH Plus), Group 2 (IRoot SP), and Group3 (Epiphany-Resilon root canal filling system) respectively. Conclusion: The three tested sealers had the similar capability in apical sealing.