ckground: Visfatin was reported to exert various pro-inflammatory function. The present
study aims to evaluate the level of visfatin in gingival crevicular fluid (GCF) and assess this
relationship in individuals with diabetes mellitus type 2 (T2DM) and periodontitis (P) before and
following nonsurgical periodontal therapy (NSPT).
Patients and methods: Forty-five subjects were enrolled in this study and equally divided into
three groups, group 1: healthy participants, group 2: patients with diabetes mellitus (T2DM) and
periodontitis and group 3: patients with periodontitis only. Clinical parameters were recorded at
baseline and after NSPT at 1, 3 and 6 months, visfatin levels were also assessed at the same time
intervals using enzyme-linked immunosorbent assay.
Results: GCF visfatin level at baseline showed a significantly lower concentration in healthy
participants than in patients with periodontitis and T2DM and those with periodontitis only. A
significant reduction in GCF visfatin level was observed in groups 2 and 3 following NSPT at 1, 3
and 6 months.
Conclusion: The non-surgical periodontal therapy can significantly reduce GCF visfatin levels
in patients with T2DM and periodontitis and those with only periodontitis. Furthermore, visfatin
may be suggested as an inflammatory marker for periodontitis.