Temporomandibular joint (TMJ) disorders are utterly described by joint dysfunction and/or pain. Temporomandibular joint internal derangement is the most frequently reported temporomandibular disorder. Several methods have been used for the management of TMJ internal derangement ranging from conservative occlusal splints and physiotherapy, to minimally invasive arthrocentesis and to open joint invasive surgical procedures. All of which aim to restore function and relief affected joints pain. Current study aimed on clinically evaluating the effect of using injectable platelet rich fibrin as an injection drug in the temporomandibular joint following arthrocentesis procedure. Results of our study revealed that the injectable PRF group was superior to the normal arthrocentesis group in pain relief, rapidity and amount of regain of the maximum mouth opening and in the resolution of the joint noise. Concluding that intra-articular PRF injection of the TMJ was a significantly effective treatment method for the treatment of internal derangement of the temporomandibular joint.