ABSTRACT
Objectives: The purpose of this study was to assess the effect of SYMBIOS® biphasic bone
graft material (BGM) in combination with autologous platelets rich fibrin (PRF) on the bone
regeneration in the treatment of odontogenic maxillary cysts.
Materials and methods: A total of twenty eight patients suffering from large maxillary
odontogenic cysts were treated by enucleation and were randomly assigned into two groups.
Each group was formed of fourteen patients. The bony defects were grafted by a combination
of SYMBIOS® and PRF in group (A) and application of SYMBIOS® alone in group (B). Postoperative
clinical and radiographic follow-up were performed. Pain and swelling scores were
measured using VAS at 6 weeks postoperative follow up, while bone density of the bony defects
were measured using cone beam computerized tomography (CBCT) at 9 months post-operative
follow up.
Results: Accelerated wound healing was observed in all cases without any signs of postoperative
complications. On the 9th month post-operatively the bone density was increased by
45.03% in group (A) where is the results of group B.
Conclusion: SYMBIOS®/PRF combination accelerated bone healing and improved the quality
and quantity of regenerated bone rather than SYMBIOS® alone.